Opgelet : de voorbereidingskalender is nog onderhevig aan wijzigingen.
| Donderdag | 15-07-21 | Training | 19:30 | ||
| Zaterdag | 17-07-21 | Training | 10:30 | ||
| Dinsdag | 20-07-21 | Training | 19:30 | ||
| Donderdag | 22-07-21 | Training | 19:30 | ||
| Zaterdag | 24-07-21 | VR | Robur - KFC Vrasene GEANNULEERD | -:- | |
| Dinsdag | 27-07-21 | Training | 19:30 | ||
| Woensdag | 28-07-21 | VR | KFC Vrasene - FC Lembeke | 19:30 | 2-5 |
| Vrijdag | 30-07-21 | Training | 19:30 | ||
| Zaterdag | 31-07-21 | KFC Moerbeke - KFC Vrasene | 18:00 | 2-6 | |
| Zondag | 01-08-21 | BOVL | KFC Vrasene - FCH Sint-Pauwels | 16:00 | 7-0 |
| Dinsdag | 03-08-21 | Training | 19:30 | ||
| Woensdag | 04-08-21 | VR | KFC Vrasene - SKL Doorslaar + training | 19:30 | 1-0 |
| Vrijdag | 06-08-21 | Training | 19:30 | ||
| Zaterdag | 07-08-21 | VR | KFC Vrasene - Sint-Gillis-Waas | 19:30 | 5-0 |
| Zondag | 08-08-21 | BOVL | FCH Sint-Pauwels - KFC Vrasene | 16:00 | 0-5 |
| Dinsdag | 10-08-21 | Training | 19:30 | ||
| Woensdag | 11-08-21 | VR | Kemzeke - KFC Vrasene + training | 19:30 | 1-1 |
| Vrijdag | 13-08-21 | Training | 19:30 | ||
| Zaterdag | 14-08-21 | SK Sint-Niklaas - KFC Vrasene | 19:30 | 3-0 | |
| Zondag | 15-08-21 | BOVL | Hoogeinde - KFC Vrasene | 16:00 | 1-3 |
| Dinsdag | 17-08-21 | Training | 19:30 | ||
| Woensdag | 18-08-21 | VR | Assenede - Beloften | 19:00 | 7-7 |
| Woensdag | 18-08-21 | VR | KFC Vrasene - Assenede GEANNULEERD | -:- | |
| Vrijdag | 20-08-21 | Training | 19:30 | ||
| Zaterdag | 21-08-21 | VR | KAV Dendermonde - KFC Vrasene GEANNULEERD | 19:30 | |
| Zondag | 22-08-21 | BOVL | Zeveren Sportief - KFC Vrasene | 16:00 | 0-2 |
| Dinsdag | 24-08-21 | Training | 19:30 | ||
| Donderdag | 26-08-21 | VR | Beloften - FC Lebbeke + Training | 19:30 | 4-2 |
| Vrijdag | 27-08-21 | Training | 19:30 | ||
| Zondag | 29-08-21 | BOVL | FC Poesele - KFC Vrasene | 16:00 | 2-1 |
| Dinsdag | 31-08-21 | Training | 19:30 | ||
| Donderdag | 02-09-21 | Training | 19:30 | ||
| Vrijdag | 03-09-21 | Training (selectie A-kern) | 19:00 | ||
| Vrijdag | 03-09-21 | COMP | Beloften - SK Beveren | 20:00 | |
| Zondag | 05-09-21 | COMP | JV Kruibeke - KFC Vrasene | 15:00 |